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Three of the most important discoveries in breast cancer research

Nevertheless, he saw an opportunity and through his mentors, trained himself to re-invent a failed "morning-after pill" to become tamoxifen, the gold standard for the treatment and prevention of breast cancer. The fact that ER-positive breast cancers are identifiable by this characteristic allowed scientists to develop ways to use oestrogen receptors as a target for treatment. It was subsequently discovered that these receptors sit in the outer membrane of cells and soak up the hormone oestrogen. It is estimated that at least a million discoverer of breast cancer worldwide are alive today because of the clinical application of Jordan's laboratory research.

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This work led to the development of the antibody trastuzumab also called Herceptinwhich in finished clinical trials with remarkable results. National Cancer Institute. One PARP inhibitor, called olaparibis currently approved to treat people with a particular type of ovarian cancer, and clinical trials are ongoing in breast, stomach and pancreatic cancer. Researchers called these HER-2 positive breast cancers.

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Discoverer of breast cancer
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